Insulin resistance compromises midbrain organoid neural activity and metabolic efficiency predisposing to Parkinsons disease pathology
Alise Žagare, Jānis Kurlovičs, Catarina Serra-Almeida, Daniele Ferrante, Daniela Frangenberg, Laura Neises, Armelle Vitali, Gemma Gomez‐Giro, Christian Jäger, Paul M. A. Antony, Rashi Halder, Rejko Krüger, Enrico Glaab, Johannes Meiser, Egils Stalidzāns, , Jens Christian Schwamborn
This study shows insulin resistance in midbrain organoids reduces metabolic efficiency and neural activity, contributing to Parkinson's disease pathology.
bioRxiv · May 3, 2024 · PreprintNeuroscience