Alise Žagare

This study uses human iPSC-derived cells to model replicative senescence in neural progenitors and shows it induces astrocyte senescence in 2D cultures and midbrain organoids, linking it to Parkinson's disease.

This study uses iPSC-derived neurons and midbrain organoids with SNCA triplication to show autophagy defects correlate with -Synuclein pathology and neuronal loss in Parkinson's disease.

This study creates vascularized midbrain organoids to model Parkinson's disease, showing increased neuroinflammation and dopaminergic neuron vulnerability in patient-derived assembloids.

This study shows that patient-derived microglia in midbrain organoids induce endogenous alpha-synuclein pathology without exogenous seeding.

This study evaluates the reproducibility of midbrain organoid data from healthy individuals and GBA-N370S PD patients across batches and time points, showing consistent transcriptomic and metabolic signatures.

The paper integrates multi-modal data to identify shared molecular dysregulation across Parkinson's disease variants, finding common transcriptomic features in glial cells and potential involvement of ROBO signalling.

This study shows that a Miro1 mutation causes mitochondrial dysfunction and dopaminergic neuron loss in both cell models and mice, supporting its role in Parkinson's disease.

This study shows insulin resistance in midbrain organoids reduces metabolic efficiency and neural activity, contributing to Parkinson's disease pathology.

The paper introduces the Virtual Metabolic Human database, which integrates human and gut microbiome metabolism with nutrition and disease data to support biomedical research.