Daniele Ferrante

Examining Action Potential Waveform Diversity in Neuronal Populations of Midbrain Organoid Models

This study uses electrophysiological recordings from midbrain organoids to cluster action potential waveforms and identifies three categories, one potentially from dopaminergic neurons.

Replicative senescence of neural progenitors induces astrocyte senescence in 2D cultures and human midbrain organoids

This study uses human iPSC-derived cells to model replicative senescence in neural progenitors and shows it induces astrocyte senescence in 2D cultures and midbrain organoids, linking it to Parkinson's disease.

Autophagy Dysfunction in iPSCs-Derived Neurons and Midbrain Organoids Carrying a SNCA Triplication

This study uses iPSC-derived neurons and midbrain organoids with SNCA triplication to show autophagy defects correlate with -Synuclein pathology and neuronal loss in Parkinson's disease.

Insulin resistance compromises midbrain organoid neural activity and metabolic efficiency predisposing to Parkinsons disease pathology

This study shows insulin resistance in midbrain organoids reduces metabolic efficiency and neural activity, contributing to Parkinson's disease pathology.