Endosomal GPR65 signaling in fibroblast-like synoviocytes promotes inflammatory cytokine release and nociceptive neuron sensitization.
Luke A. Pattison, Maya Dannawi, Ewan St. John Smith
The paper shows that GPR65 internalization in fibroblast-like synoviocytes is necessary for ERK activation and cytokine release, which sensitize nociceptive neurons.