Author

Helen Hilton

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Luke A. PattisoniD· 3 shared Ewan St. John SmithiD· 2 shared Maya DannawiiD· 2 shared Rebecca H. RickmaniD· 2 shared Alex J. ClarkiD· 1 shared Alexander CloakeiD· 1 shared Anne RitouxiD· 1 shared David BennettiD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersNeuroscience

Luke A. PattisonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain.

Luke A. Pattison, Rebecca H. Rickman, Helen Hilton, Maya Dannawi, Susanne N. Wijesinghe, Graham Ladds, Li V. Yang, Simon Wyn Jones, Ewan St. John Smith

This study shows that activating GPR65 on fibroblast-like synoviocytes leads to inflammatory mediator release, contributing to joint pain in mice and humans.

Proceedings of the National Academy of Sciences · Dec 11, 2024Peer-reviewedNeuroscience

Digging deeper into pain - an ethological behavior assay correlating well-being in mice with human pain experience.

Luke A. Pattison, Alexander Cloake, Sampurna Chakrabarti, Helen Hilton, Rebecca H. Rickman, James P. Higham, Michelle Y. Meng, Luke W Paine, Maya Dannawi, Lanhui Qiu, Anne Ritoux, David Colin Bulmer, Gerard Callejo, Ewan St. John Smith

This study correlates mouse digging behavior with human pain experience, showing that digging deficits reflect pain levels and that meloxicam is more effective than gabapentin in alleviating these deficits.

Pain · Mar 5, 2024Peer-reviewedNeuroscience

Inhibition of sensory neuron driven acute, inflammatory, and neuropathic pain using a humanised chemogenetic system

Jimena Pérez-Sánchez, Steven J. Middleton, Luke A. Pattison, Helen Hilton, Mosab Ali Awadelkareem, Sana R. Zuberi, Maria B. Renke, Huimin Hu, Xun Yang, Alex J. Clark, Ewan St, John Smith, David Bennett

This study demonstrates the efficacy of a humanised chemogenetic system in silencing sensory neuron hyperexcitability and reducing pain in both mouse and human models.

bioRxiv · Mar 21, 2023 · PreprintNeuroscience