Aurélien Villedieu

Actin and myosin dynamics during epithelial remodeling in avian gastrulation

This study investigates actin and myosin dynamics during epithelial remodeling in avian gastrulation, showing that junctional myosin contraction drives cell rearrangements and primitive streak formation.

Tissue mechanics sets developmental scaling of collective cell migration

The paper shows that tissue mechanics, not gene patterning, determine the scaling of collective cell migration velocity with tissue size during development.

Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction

The paper uses live imaging to show that avian hypoblast movement and patterning are consequences of NODAL signaling, not drivers of primitive streak induction.

A tension-induced morphological transition shapes the avian extra-embryonic territory

The paper investigates how tension during epiboly drives morphological changes in avian extra-embryonic cells, leading to the formation of the primitive streak.

Self-organized tissue mechanics underlie embryonic regulation

The paper shows mechanical forces in avian embryos self-organize like a Turing model, guiding tissue flows and gene expression to form embryos, even under perturbations.

Homeotic compartment curvature and tension control spatiotemporal folding dynamics.

The paper shows how curvature and tension in Drosophila homeotic compartments drive spatiotemporal folding during development.

Multi-view confocal microscopy enables multiple organ and whole organism live-imaging

The paper introduces MuViScopy, a multi-view confocal microscopy technique for live-imaging multiple organs and whole organisms without embedding, demonstrating its use in Drosophila pupal development.