François Graner

Tissue mechanics sets developmental scaling of collective cell migration

The paper shows that tissue mechanics, not gene patterning, determine the scaling of collective cell migration velocity with tissue size during development.

Three phylogenetic metrics are compatible with natural evolution of the earliest SARS-CoV-2 sequence

The paper develops a method to detect recombination breakpoints and signs of human-made manipulation in viral sequences, finding no evidence of such manipulation in SARS-CoV-1, MERS-CoV, or SARS-CoV-2.

Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation

This study uses a cellular Potts model to show that apical constriction requires patterned apical surface remodeling to synchronize cellular deformation and prevent tissue invagination.

Apical-driven cell sorting optimised for tissue geometry ensures robust patterning

The paper shows apical polarity in PrE cells drives robust tissue patterning in blastocysts by guiding migration and breaking symmetry.

Adhesive and mechanical properties of the glue produced by 25 Drosophila species

This study measures adhesive and mechanical properties of Drosophila glue across 25 species, finding variation linked to ecological factors and identifying D. hydei as a promising model for bioadhesives.

Homeotic compartment curvature and tension control spatiotemporal folding dynamics.

The paper shows how curvature and tension in Drosophila homeotic compartments drive spatiotemporal folding during development.

From heterogenous morphogenetic fields to homogeneous regions as a step towards understanding complex tissue dynamics

This study proposes a method to identify regions in developing tissues with distinct cellular dynamics and deformation, using image segmentation, clustering, and boundary smoothing.

Cell shape anisotropy and motility constrain self-organised feather pattern fidelity in birds

The paper shows that cell shape anisotropy and motility influence the precision of feather pattern formation across bird species.

Lumen expansion facilitates epiblast-primitive endoderm fate specification in the mouse blastocyst formation.

This study shows that lumen expansion in mouse blastocysts is critical for epiblast and primitive endoderm fate specification and spatial segregation.