Di-Gluebodies as covalently-rigidified, modular protein assemblies enable simultaneous determination of high-resolution, low-size, cryo-EM structures
Gangshun Yi, Dimitrios Mamalis, Mingda Ye, Loïc Carrique, M. Fairhead, Huanyu Z. Li, Katharina L. Duerr, Peijun Zhang, David Bryant Sauer, F. von Delft, Benjamin G. Davis, Robert J.C. Gilbert
The paper introduces Di-Gluebodies, covalently-dimerized nanobodies, to improve cryo-EM structure determination of small proteins by providing rigidity and modularity.
Nature Chemical Biology · Aug 15, 2025Peer-reviewedSynthetic Biology