Author

Olivier Mirguet

ORCID 0000-0002-5486-0386Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Abraham van Wyk· 1 shared Alexandra C. TitleiD· 1 shared Emme Fishburn· 1 shared Erwin IlegemsiD· 1 shared Gurprit BhardwajiD· 1 shared Kavit RavaliD· 1 shared Oppel B.W. Greeff· 1 shared Paul D. Ratcliffe· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperCell Biology

Abraham van Wyk

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1 paper

Recent·Most cited

Targeting PFKFB3 Metabolic Gatekeeping of β-Cell Dysfunctional States Enables Durable Glucose Tolerance in Type 2 Diabetes

Kavit Raval, Erwin Ilegems, Alexandra C. Title, Emme Fishburn, Gurprit Bhardwaj, Olivier Mirguet, Paul D. Ratcliffe, Oppel B.W. Greeff, Abraham van Wyk, Slavica Tudzarova

This study shows that inhibiting PFKFB3 improves glucose tolerance in type 2 diabetes by restoring β-cell function and reducing dysfunctional states, with effects lasting after treatment stops.

bioRxiv · Sep 22, 2026 · PreprintCell Biology