Author

Kavit Raval

University of California, Los AngelesORCID 0000-0003-0086-8312Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Slavica TudzarovaiD· 2 shared Abraham van Wyk· 1 shared Alexandra C. TitleiD· 1 shared Berfin SeyraniD· 1 shared Emme Fishburn· 1 shared Erwin IlegemsiD· 1 shared Feiyang MaiD· 1 shared Gurprit BhardwajiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Slavica TudzarovaORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 22, 2026

Targeting PFKFB3 Metabolic Gatekeeping of β-Cell Dysfunctional States Enables Durable Glucose Tolerance in Type 2 Diabetes

Kavit Raval, Erwin Ilegems, Alexandra C. Title…·Slavica Tudzarova

This study shows that inhibiting PFKFB3 improves glucose tolerance in type 2 diabetes by restoring β-cell function and reducing dysfunctional states, with effects lasting after treatment stops.

DOI 10.64898/2026.09.20.752954

mousehuman

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Cell BiologyLife Science AlliancePeer-reviewedSep 23, 2024

Dysfunctional β-cell longevity in diabetes relies on high energy conservation and positive epistasis

Kavit Raval, Neema Jamshidi, Berfin Seyran…·Slavica Tudzarova

The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.

9 citations

humanmouse

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