Author

Slavica Tudzarova

University of California, Los AngelesORCID 0000-0002-9617-3779Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Gurprit BhardwajiD· 2 shared Kavit RavaliD· 2 shared Abraham van Wyk· 1 shared Alexandra C. TitleiD· 1 shared Anita Krnjic· 1 shared Berfin SeyraniD· 1 shared Emme Fishburn· 1 shared Erwin IlegemsiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPhysiology

Gurprit BhardwajORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

PFKFB3 inhibition restores β-cell responsiveness to acetylcholine in a 3xTg-AD pancreatic tissue-slice mode

Johannes U. Pfabe, Sandra Postić, Lea Miglinci, Anita Krnjic, Hifza Ahmed, Tobias Eisenberg, Jelena Tadić, Kavit H Raval, Gurprit Bhardwaj, Slavica Tudzarova, Marjan Slak Rupnik

This study shows that PFKFB3 inhibition restores β-cell Ca2+ signaling responsiveness to acetylcholine in 3xTg-AD pancreatic tissue slices.

bioRxiv · Oct 7, 2026 · PreprintPhysiology

Targeting PFKFB3 Metabolic Gatekeeping of β-Cell Dysfunctional States Enables Durable Glucose Tolerance in Type 2 Diabetes

Kavit Raval, Erwin Ilegems, Alexandra C. Title, Emme Fishburn, Gurprit Bhardwaj, Olivier Mirguet, Paul D. Ratcliffe, Oppel B.W. Greeff, Abraham van Wyk, Slavica Tudzarova

This study shows that inhibiting PFKFB3 improves glucose tolerance in type 2 diabetes by restoring β-cell function and reducing dysfunctional states, with effects lasting after treatment stops.

bioRxiv · Sep 22, 2026 · PreprintCell Biology

Dysfunctional β-cell longevity in diabetes relies on high energy conservation and positive epistasis

Kavit Raval, Neema Jamshidi, Berfin Seyran, Łukasz Salwiński, Raju K. Pillai, Lixin Yang, Feiyang Ma, Matteo A. Pellegrini, Juliana Shin, Xia Yang, Slavica Tudzarova

The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.

Life Science Alliance · Sep 23, 2024Peer-reviewedCell Biology