Insulin Signaling-independent Activation of DAF-16 Shapes the Transcriptome during Normal Aging
Shang‐Tong Li, Hanqing Zhao, Pan Zhang, Chung‐Yi Liang, Yanping Zhang, Ao‐Lin Hsu, Meng‐Qiu Dong
This study shows that DAF-16, a transcription factor, activates gene expression during aging in C. elegans independently of insulin signaling, stabilizing the transcriptome against age-related stress.
bioRxiv · Mar 22, 2018 · PreprintSystems Biology