This study presents a single-nucleus transcriptomic atlas of Drosophila treated with rapamycin, identifying a sex-biased convergent aging trajectory and its modulation by rapamycin.

bioRxiv · Jul 3, 2026 · PreprintDevelopmental Biology

Whole organism snRNA-seq reveals systemic peripheral changes in Alzheimer's Disease fly models

Ye-Jin Park, Tzu‐Chiao Lu, Tyler Jackson, Lindsey D. Goodman, L. Ran, Jiaye Chen, Chung‐Yi Liang, Erin M Harrison, Christina Ko, Xi Xian Chen, Baiping Wang, Ao‐Lin Hsu, Elizabeth Ochoa, Kevin F. Bieniek, Shinya Yamamoto, , Hongjie Li

The paper uses snRNA-seq in Drosophila to study how AD-associated proteins affect peripheral tissues, finding distinct impacts of Aβ42 and Tau on sensory neurons and non-neuronal tissues.

Neuron · Jul 1, 2025Peer-reviewedGenetics

HSB-1 inhibition and HSF-1 overexpression trigger overlapping transcriptional changes to promote longevity in Caenorhabditis elegans

Surojit Sural, Tzu‐Chiao Lu, Seung Ah Jung, Ao‐Lin Hsu

The paper shows that inhibiting HSB-1 and overexpressing HSF-1 in C. elegans lead to overlapping transcriptional changes that promote longevity.

G3 Genes Genomes Genetics · Mar 20, 2019Peer-reviewedGenetics

Insulin Signaling-independent Activation of DAF-16 Shapes the Transcriptome during Normal Aging

Shang‐Tong Li, Hanqing Zhao, Pan Zhang, Chung‐Yi Liang, Yanping Zhang, Ao‐Lin Hsu, Meng‐Qiu Dong

This study shows that DAF-16, a transcription factor, activates gene expression during aging in C. elegans independently of insulin signaling, stabilizing the transcriptome against age-related stress.

bioRxiv · Mar 22, 2018 · PreprintSystems Biology