Structural basis for catalytic and inhibitory divergence between archaeal and bacterial ammonia monooxygenases
Xiaoyun Yang, Tieqiang Mao, Zhi-Cong He, Yan Chen, Guoping Zhao, Peng Jin, Shengying Li, Hongpo Dong, Wei Peng, Chuanlun Zhang, Zongqiang Li
Archaeal ammonia monooxygenase (AMO) is a cup-shaped homotrimer using a mononuclear CuD site; inhibitors bind bacterial AMO's dicopper center directly but apparently inactivate archaeal AMO indirectly by relocating copper.
bioRxiv · Sep 1, 2026 · PreprintMolecular Biology✦ In-depth digest