Guoping Zhao

This study identifies EccB5 as a key Mtb effector that drives pyroptosis and enhances virulence by interacting with GSDMD and caspase-1.

Archaeal ammonia monooxygenase (AMO) is a cup-shaped homotrimer using a mononuclear CuD site; inhibitors bind bacterial AMO's dicopper center directly but apparently inactivate archaeal AMO indirectly by relocating copper.

The paper introduces xAI-MTBDR, an AI framework that identifies drug resistance mutations in MTB and predicts resistance, outperforming existing methods and revealing new resistance markers.