Lee Davidson

The paper shows mammalian RNA polymerase II can terminate transcription at T-tracts, a mechanism also seen in prokaryotes and RNAPIII, and demonstrates this occurs genome-wide in promoter-proximal regions.

The paper shows that sense transcription is more efficient than antisense initiation and that CDK9 and INTS11 opposingly maintain directionality in mammalian promoters.

This study identifies ZC3H4 as a factor that restricts non-coding transcription in human cells by promoting degradation of unstable transcripts, particularly antisense RNAs and super-enhancer transcripts.