Author

Matteo Boretto

Oncode InstituteORCID 0000-0002-5515-204XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Approach:simulation· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Ruben van BoxteliD· 2 shared Amanda Andersson-RolfiD· 1 shared Andrea GuarracinoiD· 1 shared Arianne M. BrandsmaiD· 1 shared Cayetano Pleguezuelos‐ManzanoiD· 1 shared Eline J.M. BertrumsiD· 1 shared Elizaveta KulaevaiD· 1 shared Eyleen de Poel· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Ruben van BoxtelORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 30, 2026

Somatic variant detection using an individual-specific pangenome reference: a case study of a pediatric acute myeloid leukemia patient

Elizaveta Kulaeva, Eline J.M. Bertrums, Markus J. van Roosmalen…·Andrea Guarracino

This study evaluates the impact of an individual-specific pangenome on somatic variant calling in a pediatric AML patient, finding reduced false positives and altered phylogenetic branching.

DOI 10.64898/2026.10.27.756267

humanwhole-genome sequencing

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GeneticsLife Science AlliancePeer-reviewedAug 9, 2021

Evaluating CRISPR-based Prime Editing for cancer modeling and CFTR repair in intestinal organoids

Maarten H. Geurts, Eyleen de Poel, Cayetano Pleguezuelos‐Manzano…·Hans C. Clevers

This study evaluates prime editing for modeling cancer mutations and repairing CFTR in intestinal organoids, showing its potential but also highlighting challenges in efficiency and off-target effects.

151 citationstop 1%

humanexperimental assay

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