Hilde Smeenk

This paper introduces a method to generate adherent cortical organoids in a multiwell format, showing reproducible 3D cortical layer formation and potential for drug discovery and disease modeling.

This study shows that Influenza A Virus infection impairs neuronal activity in human iPSC-derived neural co-cultures without causing cell death or efficient virus replication.

The paper identifies a novel pathway where astrocytes clear pre-synaptic autophagosomes from neurons through a cholesterol-dependent endocytosis process without requiring direct cell contact or retrograde transport.

This study develops a method to differentiate human pluripotent stem cells into functional astrocytes in 28 days, validated by marker expression and network activity support.