Author
Cancer Research UK Scotland InstituteORCID 0000-0002-5543-2789Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Rosalie Heilig, Hannah Glover, Charlotte E. L. Mellor…·Stephen WG Tait
This study identifies RNF213 as an E3 ligase that catalyzes M1-linked ubiquitination of damaged mitochondria, activating pro-inflammatory NF-κB signaling through NEMO recruitment.
Flora McNulty, Andrew M. Shaw, Amy Shepherd…·Payam A. Gammage
The paper identifies a conserved mechanism regulating mtDNA copy number through compartmentalization of redox co-factors across eukaryotes.
Sarah Laing, Isabel Dye, Ryan M. Byrne…·Daniel J. Murphy
The paper identifies high MYC activity as a targetable feature in lung adenocarcinoma using phenotype-based subtyping and shows sensitivity to a dual inhibitor of MYC co-factors.
Eguzkine Ochoa, Verena Zuber, Nora Fernández‐Jiménez…·Leonardo Bottolo
MethylCal is a Bayesian tool that calibrates methylation levels by jointly analyzing CpGs in DMRs or CpG islands, improving accuracy in methylation quantification and clinical applications.