Author

Ryan M. Byrne

Queen's University BelfastORCID 0000-0001-6505-6345Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Philip D. DunneiD· 3 shared Sudhir B. MallaiD· 3 shared Aideen E. RyaniD· 2 shared Courtney BulliD· 2 shared Mark LawleriD· 2 shared Natalie C. FisheriD· 2 shared Raheleh AmirkhahiD· 2 shared Shania M. CorryiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Philip D. DunneORCID

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3 papers

Recent·Most cited

Cancer BiologyCommunications BiologyPeer-reviewedMay 26, 2026

Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state

Shania M. Corry, Svetlana S. Sakhnevych, Noha Ehssan Mohamed…·Philip D. Dunne

This study shows that poly(I:C) treatment in CMS4 colorectal tumors induces a pro-inflammatory, CMS1-like regenerative state and identifies biomarkers for predicting therapeutic response.

DOI 10.1038/s42003-026-10295-9

humanbulk RNA-seq

Cancer BiologybioRxivPreprintMay 1, 2026

Phenotype-dependent subtyping exposes high MYC activity as a targetable dependency in LuAd

Sarah Laing, Isabel Dye, Ryan M. Byrne…·Daniel J. Murphy

The paper identifies high MYC activity as a targetable feature in lung adenocarcinoma using phenotype-based subtyping and shows sensitivity to a dual inhibitor of MYC co-factors.

DOI 10.64898/2026.04.27.721038

humanbulk RNA-seq

Cancer BiologyScientific ReportsPeer-reviewedDec 4, 2024

Evaluation of Gene Set Enrichment Analysis (GSEA) tools highlights the value of single sample approaches over pairwise for robust biological discovery.

Courtney Bull, Ryan M. Byrne, Natalie C. Fisher…·Sudhir B. Malla

This study compares GSEA tools and finds single sample approaches better capture biological distinctions than pairwise methods in cancer recurrence analysis.

14 citations

humanbulk RNA-seq