Alejandro Huerta Uribe

This study uses [18F]FSPG to non-invasively monitor redox changes linked to ferroptosis in tumors and assess immunotherapy effectiveness.

The paper identifies a conserved mechanism regulating mtDNA copy number through compartmentalization of redox co-factors across eukaryotes.

The paper identifies L-pentahomoserine as a bacterial metabolite linked to better survival in esophageal cancer by supporting metabolic adaptations under nutrient stress.

This paper identifies a metabolic vulnerability in leptomeningeal ALL cells due to thiol scarcity in CSF, making them susceptible to ferroptosis through disruption of selenocysteine biosynthesis and GPX4 activity.

The paper identifies glucuronidation pathway upregulation as a mechanism by which colon cancer cells develop resistance to trametinib, showing that inhibiting this pathway can reverse resistance in both Drosophila and mouse models.

This paper shows that inhibiting ABHD11 reduces T cell cytokine production and alleviates autoimmunity by altering sterol metabolism and LXR activation.

This study shows that developmental mitochondrial complex I dysfunction reduces lifespan and stress resistance, while adult-onset dysfunction increases lifespan and stress resistance.

This study shows that pyruvate from bone marrow mesenchymal stem cells supports myeloma cell redox homeostasis and anabolism through MCT-1/2 transporters.