Sérgio Lilla

Coordinated Assembly of WAVE and WASH complexes

This study identifies BRK1 and CCDC53 as key subunits in WAVE and WASH complex assembly, showing their interaction with HSBP1 and their role in regulating actin dynamics and cell migration.

RNF213 M1-ubiquitinates damaged mitochondria to activate pro-inflammatory NF-κB signaling

This study identifies RNF213 as an E3 ligase that catalyzes M1-linked ubiquitination of damaged mitochondria, activating pro-inflammatory NF-κB signaling through NEMO recruitment.

A conserved mechanism for regulation of mtDNA copy number in eukaryotes

The paper identifies a conserved mechanism regulating mtDNA copy number through compartmentalization of redox co-factors across eukaryotes.

CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge

Macrophage chemotaxis steered by complex self-generated gradients of complement C5a

This study shows mouse and human macrophages use self-generated C5a gradients for chemotaxis, with distinct degradation mechanisms and optimal concentrations.

The AMPK-related kinase NUAK1 regulates neuronal morphogenesis through the RNA splicing co-factor SON

This study identifies NUAK1 as a regulator of alternative splicing in cortical neurons through phosphorylation of SON, linking it to neurodevelopmental processes and ZTTK syndrome.

Radiotherapy drives lung metastasis in PDAC via a RhoGTPasesignaling shift towards MRCK-dependency

This study shows that radiotherapy promotes lung metastasis in PDAC by increasing MRCK activity, which can be inhibited by BDP9066.

Overcoming preservation challenges to enable single-cell proteomics of fixed cell and tissue samples with retained proteome integrity

This paper develops a method to perform single-cell proteomics on preserved tissues, expanding its applicability by overcoming sample preservation challenges.