Takeshi Matsui

This paper introduces SCRIVENER, a bacterial mating-based DNA assembly platform that enables high-throughput, low-error DNA construction of up to 23 kb constructs.

The paper identifies gene-perturbation interactions across genetic backgrounds in yeast using CRISPRi and combinatorial DNA barcode sequencing, revealing 460 genes with variable effects and 234 interacting loci.

The paper identifies genetic loci influencing fungal persistence in different mammalian organs using a yeast model, showing complex interactions between general and organ-specific alleles.

The paper identifies multiple genetic loci influencing the expressivity of a spontaneous mutation in budding yeast.

The paper shows that in diploids, epistasis frequently modifies both additivity and dominance.

The paper identifies a chromosomal duplication in yeast that enhances tolerance to oxidative stress by duplicating the TSA2 gene.