Martin N. Mullis

A multiomic lifespan signature in genetically diverse, diet-restricted mice

This study identifies molecular changes in diet-restricted mice that correlate with lifespan and aging, highlighting key genes and pathways involved in longevity.

Genetic correlation-guided mega-analysis of DO mice provides mechanistic insight and candidate genes for age-related pathologies

The paper uses genetic correlation analysis in DO mice to identify QTL and candidate genes linked to age-related pathologies.

Analysis of lifespan across Diversity Outbred mouse studies identifies multiple longevity-associated loci

This study identifies six longevity-associated loci in Diversity Outbred mice through a genetic meta-analysis of lifespan data from three studies, explaining over half of the heritable variation in lifespan.

Automated Quantitative Assessment of Elastic Fibers in Verhoeff-Van Gieson-Stained Mouse Aorta Histological Images

This paper introduces an automated pipeline to quantify elastic fiber architecture in mouse aorta histology, enabling objective, high-throughput analysis of vascular structure.

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

Genome-scale analysis of interactions between genetic perturbations and natural variation

The paper identifies gene-perturbation interactions across genetic backgrounds in yeast using CRISPRi and combinatorial DNA barcode sequencing, revealing 460 genes with variable effects and 234 interacting loci.

Complex genetics cause and constrain fungal persistence in different parts of the mammalian body

The paper identifies genetic loci influencing fungal persistence in different mammalian organs using a yeast model, showing complex interactions between general and organ-specific alleles.

Genetic basis of a spontaneous mutation's expressivity

The paper identifies multiple genetic loci influencing the expressivity of a spontaneous mutation in budding yeast.

The interplay of additivity, dominance, and epistasis in a diploid yeast cross

The paper shows that in diploids, epistasis frequently modifies both additivity and dominance.