Author

Allie K. Tolles

University of Massachusetts Chan Medical SchoolORCID 0000-0002-5569-0710Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ailsa M. JeffriesiD· 2 shared Michael A. LodatoiD· 2 shared Didem DemirbasiD· 1 shared Eunjung Alice LeeiD· 1 shared Jennifer S. ZiegenfussiD· 1 shared Jenny F. LaiiD· 1 shared Junho KimiD· 1 shared Junseok ParkiD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersNeuroscience

Ailsa M. JeffriesORCID

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2 papers

Recent·Most cited

ATM-deficiency induced microglial activation promotes neurodegeneration in Ataxia-Telangiectasia

Jenny F. Lai, Didem Demirbas, Junho Kim, Ailsa M. Jeffries, Allie K. Tolles, Junseok Park, Thomas W. Chittenden, Patrick G. Buckley, Timothy W. Yu, Michael A. Lodato, Eunjung Alice Lee

This study shows that ATM deficiency causes microglial activation, which contributes to neurodegeneration in Ataxia-Telangiectasia by inducing cytotoxicity in neurons.

Cell Reports · Dec 28, 2023Peer-reviewedNeuroscience

Single-cell transcriptomic and genomic changes in the aging human brain

Ailsa M. Jeffries, Tianxiong Yu, Jennifer S. Ziegenfuss, Allie K. Tolles, Yerin Kim, Zhiping Weng, Michael A. Lodato

The paper identifies transcriptomic and genomic changes in the aging human brain using single-nucleus RNA-sequencing and single-cell whole-genome sequencing, revealing age-related gene expression patterns and somatic mutation dynamics.

bioRxiv · Nov 7, 2023 · PreprintGenomics