Author

Daphne Chen

University of California, San FranciscoORCID 0000-0002-5571-3548Unclaimed ORCID profile · follow to get notified of new preprints

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Daphne Chen2 papers · Karolinska Institutet

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Adair L. BorgesiD· 1 shared Alan AshworthiD· 1 shared Dominique H. SmithiD· 1 shared G. J. CorreyiD· 1 shared James S. FraseriD· 1 shared Jenny Y. ZhangiD· 1 shared Joseph Bondy‐DenomyiD· 1 shared Leah T. RoeiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Adair L. BorgesORCID

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1 paper

Recent·Most cited

AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid

Daphne Chen, Leah T. Roe, Yuping Li, Adair L. Borges, Jenny Y. Zhang, Palak Babbar, Sourobh Maji, Maisie GV Stevens, G. J. Correy, Morgan E. Diolaiti, Dominique H. Smith, Alan Ashworth, Robert Michael Stroud, Mark J. S. Kelly, Joseph Bondy‐Denomy, James S. Fraser

This study characterizes AcrIF11, an ADP-ribosyltransferase that inhibits CRISPR-Cas systems with high potency and specificity, and shows its reversibility through macrodomain enzymes.

mBio · Aug 14, 2025Peer-reviewedMicrobiology