Leah Tang Roe

AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid

This study characterizes AcrIF11, an ADP-ribosyltransferase that inhibits CRISPR-Cas systems with high potency and specificity, and shows its reversibility through macrodomain enzymes.

Sporadic distribution of a new archaeal genetic code with all TAG codons as pyrrolysine

The paper confirms a new archaeal genetic code (Code 34) where TAG codons encode pyrrolysine, showing sporadic distribution and lateral gene transfer.

Backbone extension acyl rearrangements enable cellular synthesis of proteins with internal β2-peptide linkages

This paper introduces a method to synthesize proteins with internal β2-peptide linkages in cells by using a post-translational rearrangement after incorporating specific -hydroxy acid monomers.

Orthogonal synthetases for polyketide precursors

This paper reports PylRS enzymes that accept non-proteinogenic monomers for in vitro translation, enabling the synthesis of sequence-defined hetero-oligomers.