A new nanoDSF approach to anti-tubulin compounds screening revealed novel MTAs among approved drugs.
Viktoriia E. Baksheeva, Romain La Rocca, Diane Allegro, Carine Derviaux, Eddy Pasquier, Philippe Roche, Xavier Morelli, François Devred, Andrey V. Golovin, Philipp O. Tsvetkov, Aurélie Tchoghandjian, Emeline Tabouret
The paper introduces a nanoDSF method to screen for anti-tubulin compounds, identifying novel MTAs among approved drugs and demonstrating its effectiveness in detecting known and new agents.
Journal of Medicinal Chemistry · Aug 15, 2025Peer-reviewedCancer Biology