Romain La Rocca

Structural basis of HSP90C, a highly active chloroplastic HSP90 chaperone from A. thaliana

This study identifies non-canonical mechanisms of HSP90C, a chloroplastic HSP90 chaperone, through structural and biophysical analyses, revealing features contributing to its high ATPase activity.

A new nanoDSF approach to anti-tubulin compounds screening revealed novel MTAs among approved drugs.

The paper introduces a nanoDSF method to screen for anti-tubulin compounds, identifying novel MTAs among approved drugs and demonstrating its effectiveness in detecting known and new agents.

Identification of the three zinc-binding sites on Tau protein

This study identifies three zinc-binding sites on the Tau protein using NMR and molecular simulations, providing insights into zinc-induced aggregation mechanisms and potential therapeutic targets.