Kristjan Eerik Kaseniit

Sequence-Independent RNA Sensing in Living Mammalian Cells

This paper introduces modulADAR, a modular RNA sensor that enables detection of short RNA subsequences by leveraging ADARs' editing capabilities, overcoming limitations of previous sequence-dependent sensors.

Post-Transcriptional Modular Synthetic Receptors

The paper introduces LIDAR, a post-transcriptional synthetic receptor platform using RNA editing to sense ligands and produce functional outputs, enabling complex multicellular behavior programming.

Genetic-Ancestry Analysis on >93,000 Individuals Undergoing Expanded Carrier Screening Reveals Limitations of Ethnicity-Based Medical Guidelines

This study analyzes genetic ancestry in 93,419 individuals to show that ethnicity-based carrier-screening guidelines are incomplete and miss carriers in at-risk populations.

Systematic Design and Comparison of Expanded Carrier Screening Panels

The paper evaluates methods for designing expanded carrier screening panels and finds that full-exon sequencing outperforms targeted genotyping in detecting affected fetuses.