Xiaowei Zhang

Efficient generation of epitope-targeted de novo antibodies with Germinal

Germinal is a generative pipeline that designs functional antibodies with nanomolar binding affinities using minimal experimental testing.

Generative steering to adapt proteins beyond native biological contexts

ProVADA adapts proteins to non-native contexts by steering a pretrained generator while preserving function, successfully converting renin and deimmunizing antibodies.

Post-Transcriptional Modular Synthetic Receptors

The paper introduces LIDAR, a post-transcriptional synthetic receptor platform using RNA editing to sense ligands and produce functional outputs, enabling complex multicellular behavior programming.