Xiaojing J. Gao

Germinal is a generative pipeline that designs functional antibodies with nanomolar binding affinities using minimal experimental testing.

This paper introduces modulADAR, a modular RNA sensor that enables detection of short RNA subsequences by leveraging ADARs' editing capabilities, overcoming limitations of previous sequence-dependent sensors.

The paper introduces a single-cell screening platform called PIVOT for functional genetics in plants, demonstrating its ability to identify cytokinin signaling regulators.

ProVADA adapts proteins to non-native contexts by steering a pretrained generator while preserving function, successfully converting renin and deimmunizing antibodies.

This paper engineers protease-based protein circuits that selectively kill RAS-mutant cancer cells and suppress tumors, showing resistance reduction and cytotoxicity independent of oncogene addiction.

The paper introduces LIDAR, a post-transcriptional synthetic receptor platform using RNA editing to sense ligands and produce functional outputs, enabling complex multicellular behavior programming.

The paper presents a workflow using machine learning to optimize protein function and reduce immunogenicity in cell and gene therapies.

This paper develops hDIRECT, a platform using human-derived proteins to control cytokine activity in cell-based therapies, demonstrating orthogonalization through protease regulation.

This paper introduces an IFFL-based CRISPR-Cas system to reduce gene expression variability, demonstrating improved dosage control for RAI1 in a mouse model.

The paper develops a modular protein secretion platform with tunable logic and control for synthetic biology applications in cell therapies.

This paper introduces a system called RELEASE that regulates protein secretion and surface display using protease-controlled mechanisms, enabling programmable intercellular communication for biomedical applications.

The paper demonstrates a viral delivery system with multiple control levels for targeted therapy using engineered components in a rabies virus model.