Conny M. Brouwers

Four new Duchenne muscular dystrophy mouse models with clinically relevant exon deletions in the human DMD gene

The paper develops four humanized DMD mouse models with specific human exon deletions to test exon skipping therapies for Duchenne muscular dystrophy.

Molecular characterization of Cdh12-SCON conditional knockout mice reveals unexpected splicing changes

The paper characterizes the SCON system in Cdh12 conditional knockout mice, revealing unintended splicing changes that affect mRNA expression.

Genotype-phenotype correlations and de novo induction of cancer stem cells in Wilms tumor initiation.

This study identifies genotype-phenotype correlations in Wilms tumor by analyzing genetically engineered mouse models with Wt1 loss or LIN28B overexpression, showing how these mutations induce cancer stem cell markers.