Daniëlle Koot

This study shows that chromosome 7 gain optimizes WNT signaling in colorectal cancer by counteracting excessive stemness from APC mutations.

This study shows that TET loss of function promotes aneuploidy, particularly chromosome 17 trisomy, which provides a proliferative advantage in iNKT cells and mESCs.

This study identifies genotype-phenotype correlations in Wilms tumor by analyzing genetically engineered mouse models with Wt1 loss or LIN28B overexpression, showing how these mutations induce cancer stem cell markers.