Dolores Malaspina

Distinct Hippocampal Cellular Pathologies Influence Cognition Across Diagnostic Categories and Distinguish Schizophrenia from Affective Psychoses

This study identifies distinct hippocampal cellular pathologies associated with cognition in schizophrenia and affective psychoses, showing differences in metabolite biomarkers between these conditions.

Do Symptom Domains Have Similar Cellular Underpinnings Across Psychiatric Diagnoses: Evidence from 3D Hippocampal MR Spectroscopy

The paper compares cellular biomarkers in psychiatric diagnoses using 3D hippocampal MR spectroscopy, finding both similarities and differences in symptom-related pathologies across affective and non-affective psychoses.

Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder

This study identifies genetic risk loci and factors underlying clinical subtypes of bipolar disorder using GWAS and meta-analysis.

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

Exomes of 24,248 schizophrenia cases and 97,322 controls implicate ultra-rare damaging variants in 10 genes, including GRIN2A and GRIA3, with odds ratios of 3 to 50.

Polygenic risk scores lack prognostic value for adults with severe mental illness

This study evaluates the prognostic value of polygenic risk scores for schizophrenia and finds they do not improve outcome prediction beyond clinical features.

Contribution of rare copy number variants to bipolar disorder risk is limited to schizoaffective cases

The study finds that rare copy number variants (CNVs) contribute to bipolar disorder risk primarily in schizoaffective disorder bipolar type cases, with differences in CNV burden and schizophrenia polygenic risk scores between subtypes.