Melvin G. McInnis

Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder

This study identifies genetic risk loci and factors underlying clinical subtypes of bipolar disorder using GWAS and meta-analysis.

Longitudinal hair cortisol in bipolar disorder and a mechanism based on HPA dynamics

This study measures longitudinal cortisol levels in bipolar disorder using hair samples and links cortisol dynamics to mood episodes through mathematical modeling.

Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response

This study shows that bipolar disorder patient-derived neurons exhibit circadian rhythm abnormalities, with lithium non-responders showing more severe deficits that can be partially reversed by temperature entrainment.

Gene-Set Enrichment with Mathematical Biology

The paper presents a method combining gene weights from mathematical biology models and gene ranks from GWAS to improve gene-set enrichment analysis for bipolar disorder.

Ankyrin-G Regulates Forebrain Connectivity and Network Synchronization via Interaction with GABARAP

This study shows that ankyrin-G regulates forebrain connectivity and network synchronization through its interaction with GABARAP, and identifies a variant linked to bipolar disorder.

Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans

The paper analyzes rare variants to uncover mutation rate heterogeneity in the human genome, identifying genomic features that influence mutation rates.

Harmonization of cortical thickness measurements across scanners and sites

ComBat, an empirical Bayes location-and-scale model from genomics, removes additive and multiplicative scanner effects from regional cortical thickness across 11 scanners while preserving age associations.