Frédéric Coin

The paper shows that genotoxic stress triggers nuclear import of EXD2 to resolve RNA-DNA hybrids at stalled RNAPII, preventing transcription-replication conflicts and maintaining genome stability.

This study shows novel synthetic ecteinascidins effectively treat melanoma by inhibiting super-enhancer-driven oncogenic transcription, even in resistant models.

The paper shows that EXD2 nuclease degrades nascent mRNAs during genotoxic stress, enabling transcription recovery after DNA repair.