Author

Jean‐Marc Egly

Centre National de la Recherche ScientifiqueORCID 0000-0002-5960-6571Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:human· 1

Frequent Co-Authors

Emmanuel CompeiD· 2 shared Frédéric CoiniD· 2 shared Jérémy SandoziD· 2 shared Lise‐Marie DonnioiD· 2 shared Philippe Catez· 2 shared Alice Brion· 1 shared Amélie ZachayusiD· 1 shared Anthony Hannus· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Emmanuel CompeORCID

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2 papers

Recent·Most cited

A nuclear trafficking checkpoint licenses resolution of RNA-DNA hybrids at stalled RNAPII to maintain genome stability under genotoxic stress

Jérémy Sandoz, Clara Capelli, Philippe Catez, Anthony Hannus, Alice Brion, Lise‐Marie Donnio, Pierre‐Olivier Mari, Jean‐Paul Concordet, Elisa Bergamin, Emmanuel Compe, Jean‐Marc Egly, Frédéric Coin

The paper shows that genotoxic stress triggers nuclear import of EXD2 to resolve RNA-DNA hybrids at stalled RNAPII, preventing transcription-replication conflicts and maintaining genome stability.

bioRxiv · Aug 13, 2025 · PreprintMolecular Biology

Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress

Jérémy Sandoz, Max Cigrang, Amélie Zachayus, Philippe Catez, Lise‐Marie Donnio, Clémence Elly, Jadwiga Nieminuszczy, Pietro Berico, Cathy Braun, Sergey Alekseev, Jean‐Marc Egly, Wojciech Niedźwiedź, Giuseppina Giglia‐Mari, Emmanuel Compe, Frédéric Coin

The paper shows that EXD2 nuclease degrades nascent mRNAs during genotoxic stress, enabling transcription recovery after DNA repair.

Nature Communications · Jan 20, 2023Peer-reviewedMolecular Biology