This study identifies ATP2B1 as a regulator of Norrin- and WNT7A/B-induced Frizzled4 signaling in endothelial cells, showing its role in CNS vascular development.

Cell Reports · Jun 25, 2026Peer-reviewedDevelopmental Biology

A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increasing PDGFB signaling

Jacklyn Levey, Miranda Howe, Kaia Douglas, Emmanuel Odame, Neal Rajvansh, Ha‐Neul Jo, Lingling Zhang, Christina Chung, Heidi Roehrich, Somasekar Seshagiri, Stéphane Angers, Zhe Chen, Harald J. Junge

This study shows that an FZD4/LRP5 agonist improves pericyte coverage and vascular integrity by enhancing PDGFB signaling in a mouse model of pericyte deficiency.

bioRxiv · Mar 17, 2026 · PreprintDevelopmental Biology

C1q limits cystoid edema by maintaining basal beta-catenin-dependent signaling and blood-retina barrier function

Lingling Zhang, Jacklyn Levey, Md. Joynal Abedin, Ha-Neul Jo, Emmanuel Odame, Miranda Howe, Kaia Douglas, Elise Thoreen, Scott W. McPherson, Heidi Roehrich, Somasekar Seshagiri, Stéphane Angers, Zhe Chen, Harald J. Junge

This study shows that C1QA maintains blood-retina barrier function and limits cystoid edema by supporting beta-catenin-dependent signaling in a mouse model of retinal disease.

JCI Insight · Oct 14, 2025Peer-reviewedNeuroscience