Systems BiologymSystemsPeer-reviewed
Metabolic imbalance limits fermentation in microbes engineered for high-titer ethanol production
Bishal Dev Sharma, Eashant Thusoo, David M. Stevenson…·Daniel G. Olson
The paper identifies thermodynamic limitations in engineered microbial strains that prevent high-titer ethanol production by analyzing metabolite profiles and thermodynamic driving forces.