Elevated levels of intracellular RNA lariats suppress the antiviral response
Chaorui Duan, Luke Buerer, Cory Bowers, Allison J. Taggart, Mara H. O’Brien, Sarah Gunasekera, Chien‐Ling Lin, Jing Wang, Yi Zeng, Jonathan P. Staley, Alger M. Fredericks, Sean F. Monaghan, Anastasia Welch, Nathaniel E. Clark, Daxing Gao, , William Guy Fairbrother
The paper shows that accumulation of intracellular RNA lariats in DBR1-null cells reduces antiviral response by desensitizing dsRNA sensors.
The Journal of Experimental Medicine · Jan 15, 2026Peer-reviewedMolecular Biology