Jonathan P. Staley

The paper investigates how Brr2p unwinds U4/U6 base pairs in yeast by disrupting U4 secondary structures and shows that an intramolecular stem loop in U4 antagonizes U4/U6 reannealing.

The paper shows that accumulation of intracellular RNA lariats in DBR1-null cells reduces antiviral response by desensitizing dsRNA sensors.

The paper estimates the impact of alternative splicing coupled with nonsense-mediated decay on gene expression levels using population-scale genomic data and perturbation experiments.

The paper introduces CoLa-seq to profile splicing timing and identifies genetic factors influencing co-transcriptional splicing in human cells.

The paper identifies the role of Prp43 in splicing termination by interacting with the 3-end of U6 snRNA, revealing a mechanism for spliceosome disassembly and substrate release.