Metabolic engineering of yeast for de novo production of kratom monoterpene indole alkaloids
M Holtz, Daniela Rago, Ida Nedermark, Frederik G. Hansson, Beata Joanna Lehka, Lea G. Hansen, Nils Emil Junge Marcussen, Wouter J. Veneman, Linda L. Ahonen, Juraithip Wungsintaweekul, Ron P. Dirks, Carlos G. Acevedo‐Rocha, Jie Zhang, Jay D. Keasling, Michael Krogh Jensen
This study engineering yeast to produce kratom monoterpene indole alkaloids through synthetic pathway reconstruction and optimization, achieving a titer of ~290 µg/L.
bioRxiv · May 22, 2024 · PreprintSynthetic Biology