M Holtz

The paper develops orthogonal quorum sensing circuits in yeast using LuxR-type systems to enable programmable intercellular communication for synthetic biology applications.

This paper demonstrates the production of galantamine in yeast through pathway engineering and optimization, achieving a 173-fold improvement over the parental strain.

This study develops biosensors for MIAs and identifies metabolic engineering hits to enhance MIA production in yeast.

This study engineering yeast to produce kratom monoterpene indole alkaloids through synthetic pathway reconstruction and optimization, achieving a titer of ~290 µg/L.