Herman P. Spaink

Zebrafish larva infection experiments plus pharmacokinetic-pharmacodynamic (PKPD) modelling gave bedaquiline's in vivo Emax and EC50 against M. marinum in about 2 months; waterborne clarithromycin barely entered larvae.

The paper investigates the cytotoxic effects of transition metal metallacarboranes on triple-negative breast cancer cells and a vertebrate model, showing significant toxicity at nanomolar concentrations.

This study shows that M. tuberculosis and M. marinum induce similar late innate immune gene responses in zebrafish larvae, supporting M. marinum as a surrogate model for tuberculosis research.

This study shows that loss of Shp1 in zebrafish leads to myeloid cell dysfunction, inflammation, and larval lethality.

The paper identifies regulatory factors and mechanisms governing transcriptome dynamics in early zebrafish embryogenesis through computational and small-RNA sequencing analyses.

This study uses Oxford Nanopore long-read sequencing to characterize microbial diversity in seawater, identifying thousands of organisms and assembling genomes from environmental samples.

The paper identifies maternal-specific non-coding RNAs involved in zebrafish development's dual translation system, complementing previously discovered RNA types.

The paper identifies maternal- and somatic-type snoRNA expression patterns in zebrafish, showing differential regulation through transcription and RNA processing.

The paper identifies embryogenesis-specific spliceosome variants in zebrafish using snRNA gene analysis and PCR-sequencing, revealing distinct snRNA variants with sequence differences in loop structures.

The paper identifies Ig switch-like recombination regions in zebrafish 45S rDNA loci that are involved in the formation of extrachromosomal circular DNA during oogenesis.

This study shows that timed BMP inhibition arrests head development at specific positions in frog embryos, suggesting BMP signaling regulates head patterning in time and space.

This paper develops a deep learning system for automated microinjection in zebrafish embryos, achieving efficiency comparable to manual methods and enabling high-throughput genome editing.

This paper presents a novel algorithm for assembling the European eel genome from nanopore sequencing reads, achieving improved contiguity and structural quality compared to previous short-read assemblies.