Tom H. M. Ottenhoff

The paper identifies lncRNA expression signatures associated with Ebola vaccine-induced immunity using RNA-sequencing data from three human cohorts.

The paper uses imaging mass cytometry to analyze granulomas in Mtb-infected non-human primates, finding that NK cell-macrophage interactions correlate with reduced tuberculosis pathology.

The paper identifies distinct antibody-based signatures and functionalities in latent and active pediatric tuberculosis, highlighting differences in humoral immune responses that may inform diagnostic and therapeutic strategies.

This study shows that M. tuberculosis and M. marinum induce similar late innate immune gene responses in zebrafish larvae, supporting M. marinum as a surrogate model for tuberculosis research.

The paper identifies gene pathways associated with neutrophil and platelet responses that are activated up to six months before TB diagnosis in whole blood.

The paper identifies reduced host transcriptomic signatures for tuberculosis using microarray data and validates them with digital PCR, showing high accuracy in distinguishing TB from other conditions and latent TB.