Revisiting flippase specificity: Drs2-Cdc50 transports multiple anionic lipid substrates
Amalie Benfeldt Purup, Pauline Funke, Cédric Montigny, Aurélie Di Cicco, Thibaud Dieudonné, Merethe Mørch Frøsig, Yugo Iwasaki, Daniel Lévy, Thomas Günther Pomorski, Rosa L. López‐Marqués, Joseph Anthony Lyons, Guillaume Lenoir
The paper shows that the Drs2-Cdc50 flippase complex transports multiple anionic lipids, not just phosphatidylserine, and identifies the role of the water network in substrate recognition.
bioRxiv · Aug 22, 2025 · PreprintBiochemistry