Julien Royet

Multisensory pathogen detection drives rapid escape and shapes host-microbe interactions in Drosophila larvae

This study identifies a rapid escape behavior in Drosophila larvae triggered by metabolically active pathogens, revealing multisensory detection mechanisms and their dual role in defense and pathogen spread.

Uracil-Driven ROS signals activate larval TrpA1-B neurons to prime the Drosophila adult gustatory response to bacterial signal

The paper identifies uracil as a bacterial signal that primes Drosophila adults to respond to peptidoglycan through Duox/ROS and TrpA1/Gr66a pathways in larval neurons.

Drosophila's sensory responses to bacterial peptidoglycan integrates positive and negative signals

This study shows that Drosophila integrates positive and negative signals from bacterial peptidoglycan (PGN) to make behavioral decisions.

Adult Drosophila aversion to caffeine requires a unique TrpA1 isoform and the PLC signaling cascade

The paper shows that caffeine aversion in Drosophila requires the TrpA1-E isoform and PLC signaling in Gr66a+ neurons.

Detection of bacteria through taste receptors primes the cellular immune response

This study shows that Drosophila larvae use taste receptors to detect bacteria, which primes their immune system and improves survival after infection.

Bacteria-derived peptidoglycan triggers an NF-kB dependent response in Drosophila gustatory neurons

The paper shows that Drosophila bitter taste neurons use the PGRP-LB receptor and NF-κB/IMD pathway to detect bacterial peptidoglycan and influence behavior.