Author

Jaewon James Lee

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-5677-2398Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Anirban MaitraiD· 2 shared John Paul SheniD· 2 shared Scott KopetziD· 2 shared Alfonso UrbanucciiD· 1 shared Alina Cornelia IugaiD· 1 shared Andrea VialeiD· 1 shared Arthi Hariharan· 1 shared Ashley B. MorrisoniD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenomics

Anirban MaitraORCID

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3 papers

Recent·Most cited

Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypes

Xianlu Laura Peng, Ian C. McCabe, Elena V. Kharitonova, Yi Xu, Ryan T. Zhao, Changfei Luan, Joseph F. Kearney, Nancy Porterfield Kren, Arthi Hariharan, Jaewon James Lee, Justin Su, P. Chan, Ashley B. Morrison, Michelle E. LaBella, Silvia G. Hererra, , Jen Jen Yeh

The paper develops a classifier, DeCAF, to identify permissive and restraining cancer-associated fibroblast subtypes from bulk RNAseq data and validates its clinical relevance across multiple cancer types.

Cell Reports Medicine · Feb 1, 2026Peer-reviewedGenomics

Tumor cell total mRNA expression shapes the molecular and clinical phenotype of cancer

Shaolong Cao, Jennifer Rui Wang, Shuangxi Ji, Yang Peng, Matthew D. Montierth, Shuai Guo, John Paul Shen, Xiao Ling Zhao, Jingxiao Chen, Jaewon James Lee, Paola A. Guerrero, Nicholas Spetsieris, Nikolai Engedal, Sinja Taavitsainen, Kaixian Yu, , Wenyi Wang

The paper quantifies tumor-specific total mRNA expression from bulk data and shows its association with clinical outcomes across 15 cancer types.

bioRxiv · Sep 30, 2020 · PreprintGenomics

Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract

Jaewon James Lee, Scott Kopetz, Eduardo Vilar, John Paul Shen, Ken Chen, Anirban Maitra

The paper examines the expression of ACE2 and TMPRSS2 in single-cell RNA sequencing datasets from different parts of the gastrointestinal tract to assess SARS-CoV-2 entry potential in enterocytes.

Genes · Jun 11, 2020Peer-reviewedBioinformatics