Yi Xu

Vulnerability of triple negative breast cancer to daraxonrasib pan-RAS(on) inhibition

This study shows that daraxonrasib, a pan-RAS(on) inhibitor, effectively inhibits TNBC cell proliferation and tumor growth, either alone or in combination with a MEK inhibitor.

Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypes

The paper develops a classifier, DeCAF, to identify permissive and restraining cancer-associated fibroblast subtypes from bulk RNAseq data and validates its clinical relevance across multiple cancer types.

Quantitative proteomic mass spectrometry of protein kinases to determine dynamic heterogeneity of the human kinome

This study quantifies kinase protein abundance in human tissues using proteomic mass spectrometry, revealing heterogeneity in breast cancer subtypes and enabling clinical applications.

Sub-Cluster Identification through Semi-SupervisedOptimization of Rare-cell Silhouettes (SCISSORS) in Single-Cell Sequencing

SCISSORS identifies rare cell types in scRNA-seq data through semi-supervised reclustering and marker gene detection.